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Publications 2018-2019

Niedergang, F.Dendritic cells mature to resist lamin degradation and herpes virus release. J Cell Biol 2019 218:387-388.
Equipe 3I Niedergang

Cecon, E., A. Ivanova, M. Luka, F. Gbahou, A. Friederich, J. L. Guillaume, P. Keller, K. Knoch, R. Ahmad, P. Delagrange, M. Solimena, and R. Jockers. 2019. Detection of recombinant and endogenous mouse melatonin receptors by monoclonal antibodies targeting the C-terminal domain. J Pineal Res 66:e12540.
Equipe EMD Jockers

Hammoudi, N., M. Dhooge, R. Coriat, S. Leblanc, M. Barret, B. Bordacahar, F. Beuvon, F. Prat, F. Maksimovic, and S. Chaussade.Duodenal tumor risk in Lynch syndrome. Dig Liver Dis 2019 51:299-303.
Equipe DRC Batteux

Peranzoni, E., and E. Donnadieu.Improving efficacy of cancer immunotherapy through targeting of macrophages. Hum Vaccin Immunother 2019 15:189-192.
Equipe 3I Donnadieu

Haidar, M., M. Metheni, F. Batteux, and G. Langsley.TGF-beta2, catalase activity, H2O2 output and metastatic potential of diverse types of tumour. Free Radic Biol Med 2019134:282-287.
Equipe 3I Ariey

Karamitri, A., and R. Jockers. Melatonin in type 2 diabetes mellitus and obesity. Nat Rev Endocrinol 2019 15:105-125.
Equipe EMD Jockers

L'Hermitte, A., S. Pham, M. Cadoux, G. Couchy, S. Caruso, M. Anson, A. M. Crain-Denoyelle, S. Celton-Morizur, S. Yamagoe, J. Zucman-Rossi, C. Desdouets, and J. P. Couty. 
Lect2 Controls Inflammatory Monocytes to Constrain the Growth and Progression of Hepatocellular Carcinoma. Hepatology 2019 69:160-178.
Equipe DRC Desdouets

Senni, N., M. Savall, D. Cabrerizo Granados, M. C. Alves-Guerra, C. Sartor, I. Lagoutte, A. Gougelet, B. Terris, H. Gilgenkrantz, C. Perret, S. Colnot, and P. Bossard. 
 beta-catenin-activated hepatocellular carcinomas are addicted to fatty acids. Gut 2019 68:322-334.
Equipe DRC Romagnolo et équipe EMD Bouillaud

Jean, C., F. Haghighirad, Y. Zhu, M. Chalbi, A. Ziyyat, E. Rubinstein, C. Gourier, P. Yip, J. P. Wolf, J. E. Lee, C. Boucheix, and V. Barraud-Lange. 
JUNO, the receptor of sperm IZUMO1, is expressed by the human oocyte and is essential for human fertilisation. Hum Reprod 2019 34:118-126.
Equipe DRC Vaiman

Bomsel, M., L. Lopalco, C. Uberti-Foppa, G. Siracusano, and Y. Ganor. 
Short Communication: Decreased Plasma Calcitonin Gene-Related Peptide as a Novel Biomarker for HIV-1 Disease Progression. AIDS Res Hum Retroviruses 2019 35:52-55.
Equipe 3I Bomsel


Publications 2018

Vaiman, D. 
Mother smoking leads to methylation anomalies on 'smoke' genes in the offspring: Indelible traces of previous injuries. EBioMedicine 2018 38:11-12.
Equipe DRC Vaiman

Gougelet, A. 
Exosomal microRNAs as a potential therapeutic strategy in hepatocellular carcinoma. World J Hepatol 2018 10:785-789.
Equipe DRC Perret

Neveu, G., F. Dupuy, M. Ladli, D. Barbieri, B. Naissant, C. Richard, R. M. Martins, J. J. Lopez-Rubio, A. Bachmann, F. Verdier, and C. Lavazec. 
Plasmodium falciparum gametocyte-infected erythrocytes do not adhere to human primary erythroblasts. Sci Rep 2018 8:17886.
Equipe 3I Lavazec et DRC Mayeux-Bouscary

Chatfield, S. M., N. Thieblemont, and V. Witko-Sarsat. 
Expanding Neutrophil Horizons: New Concepts in Inflammation. J Innate Immun 2018 10:422-431.
Equipe 3I Witko-Sarsat-Mouthon

Stoupa, A., F. Adam, D. Kariyawasam, C. Strassel, S. Gawade, G. Szinnai, A. Kauskot, D. Lasne, C. Janke, K. Natarajan, A. Schmitt, C. Bole-Feysot, P. Nitschke, J. Leger, F. Jabot-Hanin, F. Tores, A. Michel, A. Munnich, C. Besmond, R. Scharfmann, F. Lanza, D. Borgel, M. Polak, and A. Carre. 
TUBB1 mutations cause thyroid dysgenesis associated with abnormal platelet physiology. EMBO Mol Med 2018 10:e9569.
Equipe EMD Scharfmann et plateforme de microscopie éléctronique A. Schmitt

Garcia-Weber, D., A. S. Dangeard, J. Cornil, L. Thai, H. Rytter, A. Zamyatina, L. A. Mulard, and C. Arrieumerlou. 
ADP-heptose is a newly identified pathogen-associated molecular pattern of Shigella flexneri. EMBO Rep 2018 19:e46543.
Equipe EMD Bertherat

Gonzalez-Duque, S., M. E. Azoury, M. L. Colli, G. Afonso, J. V. Turatsinze, L. Nigi, A. I. Lalanne, G. Sebastiani, A. Carre, S. Pinto, S. Culina, N. Corcos, M. Bugliani, P. Marchetti, M. Armanet, M. Diedisheim, B. Kyewski, L. M. Steinmetz, S. Buus, S. You, D. Dubois-Laforgue, E. Larger, J. P. Beressi, G. Bruno, F. Dotta, R. Scharfmann, D. L. Eizirik, Y. Verdier, J. Vinh, and R. Mallone.
Conventional and Neo-antigenic Peptides Presented by beta Cells Are Targeted by Circulating Naive CD8+ T Cells in Type 1 Diabetic and Healthy Donors. Cell Metab 2018 28:946-960 e6.
Equipes EMD Lehuen-Mallone et EMD Scharfmann

Camus, M., F. Beuvon, M. Barret, E. Dalimier, H. El Bacha, S. Leblanc, R. Coriat, S. Chaussade, B. Terris, and F. Prat. 
Full-field Optical Coherence Tomography: A New Imaging Modality for Rapid On-Site Evaluation of Resected Polyps During Colonoscopy. Gastroenterology 2018 155:1692-1694.
Equipe DRC Batteux

Mouasni, S., and L. Tourneur. 
FADD at the Crossroads between Cancer and Inflammation.Trends Immunol 2018 39:1036-1053.
Equipe 3I Witko-Sarsat-Mouthon

Dehghani, L., N. Mikail, N. Kramkimel, P. Soyer, R. Lebtahi, R. Mallone, and E. Larger. 
Autoimmune pancreatitis after nivolumab anti-programmed death receptor-1 treatment. Eur J Cancer 2018 104:243-246.
Equipes EMD Scharfmann et EMD Lehuen Mallone

Bellon, A., A. Wegener, A. R. Lescallette, M. Valente, Y. Sung-Kwon, R. Gardette, J. Matricon, P. Watts, F. Mouaffak, L. Vimeux, J. K. Yun, Y. I. Kawasawa, G. Clawson, E. Blandin, B. Chaumette, T. M. Jay, M. O. Krebs, V. Feuillet, and A. Hosmalin. 
Transdifferentiation of human circulating monocytes into neuronal-like cells in 20 days and without reprograming. Frontiers Mol Neuroscience 2018 10.3389:00323.
Equipe 3I 3I Hosmalin

Ramspott, J. P., F. Bekkat, L. Bod, M. Favier, B. Terris, A. Salomon, L. Djerroudi, K. S. Zaenker, Y. Richard, V. Molinier-Frenkel, F. Castellano, M. F. Avril, and A. Prevost-Blondel. 
Emerging Role of IL-4-Induced Gene 1 as a Prognostic Biomarker Affecting the Local T-Cell Response in Human Cutaneous Melanoma. J Invest Dermatol 2018 138:2625-2634.
Equipe 3I Hosmalin et plateforme HISTIM de Maryline Favier

de Dieuleveult, M., and B. Miotto. 
DNA Methylation and Chromatin: Role(s) of Methyl-CpG-Binding Protein ZBTB38. Epigenetics Insights 2018 11:1-5.
Equipe DC Miotto

Petre, G., P. Lores, H. Sartelet, A. Truffot, B. Poreau, S. Brandeis, G. Martinez, V. Satre, R. Harbuz, P. F. Ray, F. Amblard, F. Devillard, G. Vieville, F. Berger, P. S. Jouk, D. Vaiman, A. Toure, C. Coutton, and M. Bidart.Genomic duplication in the 19q13.42 imprinted region identified as a new genetic cause of intrauterine growth restriction. Clin Genet 2018 94:575-580.
Equipe DRC Vaiman

Javary, J., N. Allain-Courtois, N. Saucisse, P. Costet, C. Heraud, F. Benhamed, R. Pierre, C. Bure, N. Pallares-Lupon, M. Do Cruzeiro, C. Postic, D. Cota, P. Dubus, J. Rosenbaum, and S. Benhamouche-Trouillet. 
Liver Reptin/RUVBL2 controls glucose and lipid metabolism with opposite actions on mTORC1 and mTORC2 signalling. Gut 2018 67:2192-2203.
Equipe EMD Postic-Issad et plateforme Recombinaison Homologue : Do Cruzeiro

Tiako Meyo, M., J. Alexandre, F. Goldwasser, and B. Blanchet.
Low-Dose Abiraterone Regimen: Drug Monitoring Might Be the Key. J Clin Oncol 2018 36:3061-62.
Equipe DRC Batteux

Plainvert, C., M. Longo, E. Seringe, B. Saintpierre, E. Sauvage, L. Ma, J. Beghain, N. Dmytruk, G. Collobert, E. Hernandez, C. Manuel, P. Astagneau, P. Glaser, F. Ariey, C. Poyart, and A. Fouet. 
A clone of the emergent Streptococcus pyogenes emm89 clade responsible for a large outbreak in a post-surgery oncology unit in France. Med Microbiol Immunol 2018 207:287-96.
Equipes 3I Poyart-Fouet et 3I langsley

Benleulmi-Chaachoua, A., A. Hegron, M. Le Boulch, A. Karamitri, M. Wierzbicka, V. Wong, I. Stagljar, P. Delagrange, R. Ahmad, and R. Jockers. 
Melatonin receptors limit dopamine reuptake by regulating dopamine transporter cell-surface exposure. Cell Mol Life Sci 2018 75:4357-4370.
Equipe EMD  Jockers

Frantz, C., C. Auffray, J. Avouac, and Y. Allanore. 
Regulatory T Cells in Systemic Sclerosis. Front Immunol 2018 9:2356.
Equipe 3I Allanore

Marchal, C., M. de Dieuleveult, C. Saint-Ruf, N. Guinot, L. Ferry, S. T. Olalla Saad, M. Lazarini, P. A. Defossez, and B. Miotto. 
Depletion of ZBTB38 potentiates the effects of DNA demethylating agents in cancer cells via CDKN1C mRNA up-regulation. Oncogenesis 2018 7:82.
Equipe DRC Miotto

Wein, M. N., M. Foretz, D. E. Fisher, R. J. Xavier, and H. M. Kronenberg. 
Salt-Inducible Kinases: Physiology, Regulation by cAMP, and Therapeutic Potential. Trends Endocrinol Metab 2018 29:723-735.
Equipe Vaulont-Viollet

Bourdon, M., P. Santulli, C. Maignien, K. Pocate-Cheriet, A. Alwohaibi, L. Marcellin, S. Blais, and C. Chapron.
The interval between oocyte retrieval and frozen-thawed blastocyst transfer does not affect the live birth rate and obstetrical outcomes. PLoS One 2018 13:e0206067.
Equipe DRC Batteux

Weckel, A., D. Ahamada, S. Bellais, C. Mehats, C. Plainvert, M. Longo, C. Poyart, and A. Fouet. 
The N-terminal domain of the R28 protein promotes emm28 group A Streptococcus adhesion to host cells via direct binding to three integrins. J Biol Chem 2018 293:16006-16018.
Equipe 3I Poyart-Fouet

Auriau, J., C. Roujeau, Z. Belaid Choucair, A. Oishi, C. Derviaux, T. Roux, E. Trinquet, O. Hermine, R. Jockers, and J. Dam. 
Gain of affinity for VEGF165 binding within the VEGFR2/NRP1 cellular complex detected by an HTRF-based binding assay. Biochem Pharmacol 2018 158:45-59.
Equipe EMD Jockers

Chapelet, A., Y. Foucher, N. Gerard, C. Rousseau, O. Zambon, C. Bretonniere, J. P. Mira, B. Charreau, and C. Guitton. 
An early increase in endothelial protein C receptor is associated with excess mortality in pneumococcal pneumonia with septic shock in the ICU. Crit Care 2018 22:251.
Equipe 3I Chiche

Backer, S., L. Lokmane, C. Landragin, M. Deck, S. Garel, and E. Bloch-Gallego. 
Trio GEF mediates RhoA activation downstream of Slit2 and coordinates telencephalic wiring. Development 2018 145:153692.
DRC Maire-Sotiropoulos

Moral-Sanz, J., S. A. Lewis, S. MacMillan, F. A. Ross, A. Thomson, B. Viollet, M. Foretz, C. Moran, D. G. Hardie, and A. M. Evans.
The LKB1-AMPK-alpha1 signaling pathway triggers hypoxic pulmonary vasoconstriction downstream of mitochondria. Sci Signal 2018 11:10.1126.
Equipe EMD Vaulont-Viollet

Kowalski, K., M. Dos Santos, P. Maire, M. A. Ciemerych, and E. Brzoska. 
Induction of bone marrow-derived cells myogenic identity by their interactions with the satellite cell niche. Stem Cell Res Ther 2018 9:258.
Equipe DRC Maire-Sotiropoulos

Ferreux, L., M. Bourdon, A. Sallem, P. Santulli, V. Barraud-Lange, N. Le Foll, C. Maignien, C. Chapron, D. de Ziegler, J. P. Wolf, and K. Pocate-Cheriet. 
Live birth rate following frozen-thawed blastocyst transfer is higher with blastocysts expanded on Day 5 than on Day 6. Hum Reprod 2018 33:390-398
Equipes DRC Batteux et DRC Vaiman

Megrelis, L., E. El Ghoul, F. Moalli, M. Versapuech, S. Cassim, N. Ruef, J. V. Stein, M. Mangeney, and J. Delon. 
Fam65b Phosphorylation Relieves Tonic RhoA Inhibition During T Cell Migration. Frontiers Immunol 2018 9:103389.
Equipe 3I Donnadieu-Randriamampita

Foretz, M., P. C. Even, and B. Viollet.
AMPK Activation Reduces Hepatic Lipid Content by Increasing Fat Oxidation In Vivo. Int J Mol Sci 2018 19:E2826.
Equipe EMD Vaulont-Viollet

Sallem, A., J. Shore, I. Ray-Coquard, L. Ferreux, M. Bourdon, C. Maignien, C. Patrat, J. P. Wolf, and K. Pocate-Cheriet. 
Fertility preservation in women with cancer: a national study about French oncologists awareness, experience, and feelings. J Assist Reprod Genet 2018 35:1843-1850.
Equipe DRC Vaiman

Douguet, L., L. Bod, L. Labarthe, R. Lengagne, M. Kato, I. Couillin, and A. Prevost-Blondel.
Inflammation drives nitric oxide synthase 2 expression by gammadelta T cells and affects the balance between melanoma and vitiligo associated melanoma. Oncoimmunology 2018 7:e1484979.
Equipe 3I Hosmalin groupe Prevost-Blondel

Hirose, M., P. Schilf, S. Rohde, Y. Gupta, T. Sancerni, M. C. Alves-Guerra, C. Sina, R. Jaster, B. Miroux, and S. M. Ibrahim. 
The mitochondrial uncoupling protein 2 gene is causal for the spontaneous polycystic liver diseases in mice. Mitochondrion 2018 42:50-53.
Equipe EMD Bouillaud

Kavian, N., S. Mehlal, M. Jeljeli, N. E. B. Saidu, C. Nicco, O. Cerles, S. Chouzenoux, A. Cauvet, C. Camus, M. Ait-Djoudi, C. Chereau, S. Kerdine-Romer, Y. Allanore, and F. Batteux. 
The Nrf2-Antioxidant Response Element Signaling Pathway Controls Fibrosis and Autoimmunity in Scleroderma. Front Immunol 2018 9:1896.
Equpe 3I Allanore et équipe DRC Batteux

Boleto, G., C. Guignabert, S. Pezet, A. Cauvet, J. Sadoine, L. Tu, C. Nicco, C. Gobeaux, F. Batteux, Y. Allanore, and J. Avouac. 
T-cell costimulation blockade is effective in experimental digestive and lung tissue fibrosis. Arthritis Res Ther 2018 20:197.
Equpe 3I Allanore et 
équipe DRC Batteux

Leblond, A., S. Pezet, A. P. Trouvin, M. Elhai, V. Gonzalez, Y. Allanore, and J. Avouac. 
Linking systemic angiogenic markers to synovial vascularization in rheumatoid arthritis. PLoS One 2018 13:e0203607.
Equipe 3I Allanore

Blanchet, B., E. Carton, M. Alyamani, L. Golmard, O. Huillard, A. Thomas-Scheomann, M. Vidal, F. Goldwasser, N. Sharifi, and J. Alexandre. 
A PK/PD study of Delta-4 abiraterone metabolite in metastatic castration-resistant prostate cancer patients. Pharmacol Res 2018 136:56-61.
Equipe DRC Batteux

Karamitri, A., B. Plouffe, A. Bonnefond, M. Chen, J. Gallion, J. L. Guillaume, A. Hegron, M. Boissel, M. Canouil, C. Langenberg, N. J. Wareham, C. Le Gouill, V. Lukasheva, O. Lichtarge, P. Froguel, M. Bouvier, and R. Jockers. 
Type 2 diabetes-associated variants of the MT2 melatonin receptor affect distinct modes of signaling. Sci Signal 2018 11:aan6622.
Equipe EMD Jockers

Camus, M., B. Napoleon, A. Vienne, M. Le Rhun, S. Leblanc, M. Barret, S. Chaussade, F. Robin, N. Kaddour, and F. Prat. 
Efficacy and safety of endobiliary radiofrequency ablation for the eradication of residual neoplasia after endoscopic papillectomy: a multicenter prospective study. Gastrointest Endosc 2018 88:511-518.
Equipe DRC Batteux

Besancon, A., Z. Demir, T. Goncalves, F. Valette, E. Panafieu, L. Chatenoud, and S. You.
Differential Impact of T-bet and IFNgamma on Pancreatic Islet Allograft Rejection. Transplantation 2018 102:1496-1504.
Equipe EMD Lehuen-Mallone

Haouzi, P., M. Gueguinou, T. Sonobe, A. Judenherc-Haouzi, N. Tubbs, M. Trebak, J. Cheung, and F. Bouillaud. 
Revisiting the physiological effects of methylene blue as a treatment of cyanide intoxication. Clin Toxicol (Phila) 2018 56:828-840.
Equipe EMD Bouillaud

Chougui, G., S. Munir-Matloob, R. Matkovic, M. M. Martin, M. Morel, H. Lahouassa, M. Leduc, B. C. Ramirez, L. Etienne, and F. Margottin-Goguet. 
HIV-2/SIV viral protein X counteracts HUSH repressor complex. Nat Microbiol 2018 3:891-897
Equipe 3I Pique-Margottin et plateforme de protéomique

Luce, S., S. Guinoiseau, A. Gadault, F. Letourneur, B. Blondeau, P. Nitschke, E. Pasmant, M. Vidaud, F. Lemonnier, and C. Boitard. 
Humanized Mouse Model to Study Type 1 Diabetes. Diabetes 2018 67:1816-1829.
EMD Bouillaud-Lombes et plateforme de génomique : Letourneur

Ramond, C., B. S. Beydag-Tasoz, A. Azad, M. van de Bunt, M. B. K. Petersen, N. L. Beer, N. Glaser, C. Berthault, A. L. Gloyn, M. Hansson, M. I. McCarthy, C. Honore, A. Grapin-Botton, and R. Scharfmann. 
Understanding human fetal pancreas development using subpopulation sorting, RNA sequencing and single-cell profiling. Development 2018 145:165480.
Equipe EMD Scharfmann

Cecon, E., A. Oishi, and R. Jockers.
Melatonin receptors: molecular pharmacology and signalling in the context of system bias. Br J Pharmacol 2018 175:3263-80.
Equipe EMD Jockers

Clement, N., N. Renault, J. L. Guillaume, E. Cecon, A. S. Journe, X. Laurent, K. Tadagaki, F. Coge, A. Gohier, P. Delagrange, P. Chavatte, and R. Jockers. 
Importance of the second extracellular loop for melatonin MT1 receptor function and absence of melatonin binding in GPR50. Br J Pharmacol 2018 175:3281-97.
Equipe EMD Jockers

Huang, H. Y., A. Rivas-Caicedo, F. Renevey, H. Cannelle, E. Peranzoni, L. Scarpellino, D. L. Hardie, A. Pommier, K. Schaeuble, S. Favre, T. K. Vogt, F. Arenzana-Seisdedos, P. Schneider, C. D. Buckley, E. Donnadieu, and S. A. Luther. 
Identification of a new subset of lymph node stromal cells involved in regulating plasma cell homeostasis. Proc Natl Acad Sci 2018 U S A 115:E6826-E6835.
Equipe 3I Donnadieu-Randriamampita 

Rouxel, O., and A. Lehuen. 
Mucosal-associated invariant T cells in autoimmune and immune-mediated diseases. Immunol Cell Biol 2018 96:618-629.
Equipe EMD Lehuen-Mallone

Terrier, B., C. Pagnoux, E. Perrodeau, A. Karras, C. Khouatra, O. Aumaitre, P. Cohen, O. Decaux, H. Desmurs-Clavel, F. Maurier, P. Gobert, T. Quemeneur, C. Blanchard-Delaunay, B. Bonnotte, P. L. Carron, E. Daugas, M. Ducret, P. Godmer, M. Hamidou, O. Lidove, N. Limal, X. Puechal, L. Mouthon, P. Ravaud, L. Guillevin, and G. French Vasculitis Study. 
Long-term efficacy of remission-maintenance regimens for ANCA-associated vasculitides. Ann Rheum Dis 2018 77:1150-1156.
Equipe 3I Witko-Sarsat-Mouthon

Stoupa, A., R. Chaabane, M. Gueriouz, C. Raynaud-Ravni, P. Nitschke, C. Bole-Feysot, M. Mnif, L. Ammar Keskes, M. Hachicha, N. Belguith, M. Polak, and A. Carre. 
Thyroid Hypoplasia in Congenital Hypothyroidism Associated with Thyroid Peroxidase Mutations. Thyroid 2018 28:941-944.
Equipe EMD Scharfman

Agosta, C., J. Laugier, L. Guyon, J. Denis, J. Bertherat, R. Libe, B. Boisson, N. Sturm, J. J. Feige, O. Chabre, and N. Cherradi. 
MiR-483-5p and miR-139-5p promote aggressiveness by targeting N-myc downstream-regulated gene family members in adrenocortical cancer. Int J Cancer 2018 143:944-957.
Equipe EMD Bertherat

Hoyles, L., J. M. Fernandez-Real, M. Federici, M. Serino, J. Abbott, J. Charpentier, C. Heymes, J. L. Luque, E. Anthony, R. H. Barton, J. Chilloux, A. Myridakis, L. Martinez-Gili, J. M. Moreno-Navarrete, F. Benhamed, V. Azalbert, V. Blasco-Baque, J. Puig, G. Xifra, W. Ricart, C. Tomlinson, M. Woodbridge, M. Cardellini, F. Davato, I. Cardolini, O. Porzio, P. Gentileschi, F. Lopez, F. Foufelle, S. A. Butcher, E. Holmes, J. K. Nicholson, C. Postic, R. Burcelin, and M. E. Dumas.
Molecular phenomics and metagenomics of hepatic steatosis in non-diabetic obese women. Nat Med 2018 24:1070-1080.
Euipqe EMD Postic-Issad

Besancon, A., T. Goncalves, F. Valette, C. Mary, B. Vanhove, L. Chatenoud, and S. You.
A selective CD28 antagonist and rapamycin synergise to protect against spontaneous autoimmune diabetes in NOD mice. Diabetologia 2018 61:1811-1816.
Equipe EMD Lehuen-Mallone

Boudaba, N., A. Marion, C. Huet, R. Pierre, B. Viollet, and M. Foretz. 
AMPK Re-Activation Suppresses Hepatic Steatosis but its Downregulation Does Not Promote Fatty Liver Development. EBioMedicine 2018 28:194-209.
EMD Vaulont-ViolletEMD Bertherat et plateforme recombinaison homologue de M. Do Cruzeiro

Bourdoulous, S., and E. Lemichez.
Decoding glycan recognition by bacterial toxins. Nat Microbiol 2018 3:124-126.
3I Bourdoulous

Brusson, M., M. De Grandis, S. Cochet, S. Bigot, M. Marin, M. Leduc, F. Guillonneau, P. Mayeux, T. Peyrard, C. Chomienne, C. Le Van Kim, B. Cassinat, J. J. Kiladjian, and W. El Nemer.
Impact of hydroxycarbamide and interferon-alpha on red cell adhesion and membrane protein expression in polycythemia vera. Haematologica 2018 103:972-981.
Plateforme Protéomique Chafey-Guillonneau-Mayeux

Hegde, P., E. Weiss, V. Paradis, J. Wan, M. Mabire, S. Sukriti, P. E. Rautou, M. Albuquerque, O. Picq, A. C. Gupta, G. Ferrere, H. Gilgenkrantz, B. Kiaf, A. Toubal, L. Beaudoin, P. Letteron, R. Moreau, A. Lehuen, and S. Lotersztajn. 
Mucosal-associated invariant T cells are a profibrogenic immune cell population in the liver. Nat Commun 2018 9:2146.
Equipe EMD Lehuen-Mallone

Deveau, P., L. Colmet Daage, D. Oldridge, V. Bernard, A. Bellini, M. Chicard, N. Clement, E. Lapouble, V. Combaret, A. Boland, V. Meyer, J. F. Deleuze, I. Janoueix-Lerosey, E. Barillot, O. Delattre, J. M. Maris, G. Schleiermacher, and V. Boeva. 
QuantumClone: clonal assessment of functional mutations in cancer based on a genotype-aware method for clonal reconstruction.Bioinformatics 2018 34:1808-1816.
Equipe DRC Boeva

Hadjadj, J., G. Canaud, T. Mirault, M. Samson, P. Bruneval, A. Regent, C. Goulvestre, V. Witko-Sarsat, N. Costedoat-Chalumeau, L. Guillevin, L. Mouthon, B. Terrier, and G. French Vasculitis Study. 
mTOR pathway is activated in endothelial cells from patients with Takayasu arteritis and is modulated by serum immunoglobulin G. Rheumatology (Oxford) 2018 57:1011-1020.
Equipe 3I Witko-Sarsat-Mouthon

Bricambert, J., M. C. Alves-Guerra, P. Esteves, C. Prip-Buus, J. Bertrand-Michel, H. Guillou, C. J. Chang, M. N. Vander Wal, F. Canonne-Hergaux, P. Mathurin, V. Raverdy, F. Pattou, J. Girard, C. Postic, and R. Dentin. 
The histone demethylase Phf2 acts as a molecular checkpoint to prevent NAFLD progression during obesity. Nat Commun 2018 9:2092.
Equipes EMD Dentin, EMD Bouillaud-LombesEMD Postic-Issad

Igonet, S., C. Raingeval, E. Cecon, M. Pucic-Bakovic, G. Lauc, O. Cala, M. Baranowski, J. Perez, R. Jockers, I. Krimm, and A. Jawhari. 
Enabling STD-NMR fragment screening using stabilized native GPCR: A case study of adenosine receptor. Sci Rep 2018 8:8142.
Equipe EMD Jockers

Abitbol, S., R. Dahmani, C. Coulouarn, B. Ragazzon, B. Mlecnik, N. Senni, M. Savall, P. Bossard, P. Sohier, V. Drouet, E. Tournier, F. Dumont, R. Sanson, J. Calderaro, J. Zucman-Rossi, M. Vasseur-Cognet, P. A. Just, B. Terris, C. Perret, and H. Gilgenkrantz. 
AXIN deficiency in human and mouse hepatocytes induces hepatocellular carcinoma in the absence of beta-catenin activation. J Hepatol 2018 68:1203-1213.
Equipe DRC Perret

Miotto, B., C. Marchal, G. Adelmant, N. Guinot, P. Xie, J. A. Marto, L. Zhang, and P. A. Defossez.
Stabilization of the methyl-CpG binding protein ZBTB38 by the deubiquitinase USP9X limits the occurrence and toxicity of oxidative stress in human cells. Nucleic Acids Res 2018 46:4392-4404.
Equipe DRC Miotto

Ohradanova-Repic, A., C. Machacek, C. Charvet, F. Lager, D. Le Roux, R. Platzer, V. Leksa, G. Mitulovic, T. R. Burkard, G. J. Zlabinger, M. B. Fischer, V. Feuillet, G. Renault, S. Bluml, M. Benko, M. Suchanek, J. B. Huppa, T. Matsuyama, A. Cavaco-Paulo, G. Bismuth, and H. Stockinger. 
Extracellular Purine Metabolism Is the Switchboard of Immunosuppressive Macrophages and a Novel Target to Treat Diseases With Macrophage Imbalances. Front Immunol 2018 9:852.
Equipe 3I Donnadieu-Randriamampita et plateforme PIV G. Renault

Olivier, S., M. Foretz, and B. Viollet. 
Promise and challenges for direct small molecule AMPK activators. Biochem Pharmacol 2018 153:147-158.
Equipe EMD Vaulont-Viollet

Tacnet-Delorme, P., J. Gabillet, S. Chatfield, N. Thieblemont, P. Frachet, and V. Witko-Sarsat. 
Proteinase 3 Interferes With C1q-Mediated Clearance of Apoptotic Cells. Front Immunol 2018 9:818.
Equipe 3I Witko-Sarsat-Mouthon

Garcin, L., D. Kariyawasam, K. Busiah, A. L. Fauret-Amsellem, F. Le Bourgeois, L. Vaivre-Douret, H. Cave, M. Polak, and J. Beltrand. 
Successful off-label sulfonylurea treatment of neonatal diabetes mellitus due to chromosome 6 abnormalities. Pediatr Diabetes 2018  19:663-669.
Equipe EMD Scharfmann

Ung, D. C., G. Iacono, H. Meziane, E. Blanchard, M. A. Papon, M. Selten, J. R. van Rhijn, R. Montjean, J. Rucci, S. Martin, A. Fleet, M. C. Birling, S. Marouillat, R. Roepman, M. Selloum, A. Lux, R. A. Thepault, P. Hamel, K. Mittal, J. B. Vincent, O. Dorseuil, H. G. Stunnenberg, P. Billuart, N. Nadif Kasri, Y. Herault, and F. Laumonnier.
Ptchd1 deficiency induces excitatory synaptic and cognitive dysfunctions in mouse.  Mol Psychiatry 2018 23:1356-1367.
Equipe DRC Billuart-Bienven

Real, F., A. Sennepin, Y. Ganor, A. Schmitt, and M. Bomsel. 
Live Imaging of HIV-1 Transfer across T Cell Virological Synapse to Epithelial Cells that Promotes Stromal Macrophage Infection. Cell Rep 2018 23:1794-1805.
Equipe 3I Bomsel et plateforme microscopie électronique Schmitt

Dejarnac, O., M. L. Hafirassou, M. Chazal, M. Versapuech, J. Gaillard, M. Perera-Lecoin, C. Umana-Diaz, L. Bonnet-Madin, X. Carnec, J. Y. Tinevez, C. Delaugerre, O. Schwartz, P. Roingeard, N. Jouvenet, C. Berlioz-Torrent, L. Meertens, and A. Amara. 
TIM-1 Ubiquitination Mediates Dengue Virus Entry. Cell Rep 2018 23:1779-1793.
Equipe 3I Berlioz-Torrent-miliani

Bourdon, M., P. Santulli, F. Kefelian, L. Vienet-Legue, C. Maignien, K. Pocate-Cheriet, J. de Mouzon, L. Marcellin, and C. Chapron. 
Prolonged estrogen (E2) treatment prior to frozen-blastocyst transfer decreases the live birth rate. Hum Reprod 2018 33:905-913.
Equipe DRC Batteux

Lecuyer, H., Z. Virion, J. P. Barnier, S. Matczak, S. Bourdoulous, E. Bianchini, F. Saller, D. Borgel, X. Nassif, and M. Coureuil. 
An ADAM-10 dependent EPCR shedding links meningococcal interaction with endothelial cells to purpura fulminans. PLoS Pathog 2018 14:e1006981.
Equipe 3I Bourdoulous

Unlu, A. H., S. Tajeri, H. B. Bilgic, H. Eren, T. Karagenc, and G. Langsley.
The secreted Theileria annulata Ta9 protein contributes to activation of the AP-1 transcription factor. PLoS One 2018 13:e0196875.
Equipe 3I Langsley

Collinot, H., C. Marchiol, I. Lagoutte, F. Lager, N. Siauve, G. Autret, D. Balvay, G. Renault, L. J. Salomon, and D. Vaiman. 
Preeclampsia induced by STOX1 overexpression in mice induces intrauterine growth restriction, abnormal ultrasonography and BOLD MRI signatures. J Hypertens 2018 36:1399-1406.
Equipe DRC Vaiman et plateforme de PIV de G. Renaud

Peranzoni, E., J. Lemoine, L. Vimeux, V. Feuillet, S. Barrin, C. Kantari-Mimoun, N. Bercovici, M. Guerin, J. Biton, H. Ouakrim, F. Regnier, A. Lupo, M. Alifano, D. Damotte, and E. Donnadieu. 
Macrophages impede CD8 T cells from reaching tumor cells and limit the efficacy of anti-PD-1 treatment. Proc Natl Acad Sci U S A 2018 115:E4041-E4050.
Equipe 3I Allanore

Touat, M., T. Sourisseau, N. Dorvault, R. M. Chabanon, M. Garrido, D. Morel, D. B. Krastev, L. Bigot, J. Adam, J. R. Frankum, S. Durand, C. Pontoizeau, S. Souquere, M. S. Kuo, S. Sauvaigo, F. Mardakheh, A. Sarasin, K. A. Olaussen, L. Friboulet, F. Bouillaud, G. Pierron, A. Ashworth, A. Lombes, C. J. Lord, J. C. Soria, and S. Postel-Vinay. 
DNA repair deficiency sensitizes lung cancer cells to NAD+ biosynthesis blockade. J Clin Invest 2018 128:1671-1687.
Equipe EMD Bouillaud-Lombes

Raynaud-Messina, B., L. Bracq, M. Dupont, S. Souriant, S. M. Usmani, A. Proag, K. Pingris, V. Soldan, C. Thibault, F. Capilla, T. Al Saati, I. Gennero, P. Jurdic, P. Jolicoeur, J. L. Davignon, T. R. Mempel, S. Benichou, I. Maridonneau-Parini, and C. Verollet. 
Bone degradation machinery of osteoclasts: An HIV-1 target that contributes to bone loss. Proc Natl Acad Sci U S A 2018 115:E2556-E2565.
Equipe 3I Bénichou

El Kennani, S., A. Adrait, O. Permiakova, A. M. Hesse, C. Ialy-Radio, M. Ferro, V. Brun, J. Cocquet, J. Govin, and D. Pflieger.  
Systematic quantitative analysis of H2A and H2B variants by targeted proteomics. Epigenetics Chromatin 2018 11:2.
Equipe DRC Vaiman

Hancili, S., A. Bonnefond, J. Philippe, E. Vaillant, F. De Graeve, O. Sand, K. Busiah, J. J. Robert, M. Polak, P. Froguel, A. Guven, and M. Vaxillaire.
A novel NEUROG3 mutation in neonatal diabetes associated with a neuro-intestinal syndrome. Pediatr Diabetes 2018 19:381-387.
Equipe EMD Scharfmann

Duchemin, M., M. Khamassi, L. Xu, D. Tudor, and M. Bomsel. 
IgA Targeting Human Immunodeficiency Virus-1 Envelope gp41 Triggers Antibody-Dependent Cellular Cytotoxicity Cross-Clade and Cooperates with gp41-Specific IgG to Increase Cell Lysis. Front Immunol 2018 9:244.
Equipe 3I Bomsel

Desdouets, C., and M. A. Avila
Inhibiting Cytokinesis in the Liver: A New Way to Reduce Tumor Development. Gastroenterology 2018 154:1229-1231.
Equipe DRC Desdouets

Wojciech, S., R. Ahmad, Z. Belaid-Choucair, A. S. Journe, S. Gallet, J. Dam, A. Daulat, D. Ndiaye-Lobry, O. Lahuna, A. Karamitri, J. L. Guillaume, M. Do Cruzeiro, F. Guillonneau, A. Saade, N. Clement, T. Courivaud, N. Kaabi, K. Tadagaki, P. Delagrange, V. Prevot, O. Hermine, C. Prunier, and R. Jockers. 
The orphan GPR50 receptor promotes constitutive TGFbeta receptor signaling and protects against cancer development. Nat Commun 2018 9:1216.
Equipe EMD Jockers et plateforme de proteomique et plateforme PRHTEC

Dong, F. N., A. Amiri-Yekta, G. Martinez, A. Saut, J. Tek, L. Stouvenel, P. Lores, T. Karaouzene, N. Thierry-Mieg, V. Satre, S. Brouillet, A. Daneshipour, S. H. Hosseini, M. Bonhivers, H. Gourabi, E. Dulioust, C. Arnoult, A. Toure, P. F. Ray, H. Zhao, and C. Coutton. 
Absence of CFAP69 Causes Male Infertility due to Multiple Morphological Abnormalities of the Flagella in Human and Mouse. Am J Hum Genet 2018 102:636-648.
Equipe DRC Vaiman

Solary, E., and M. Fontenay.
Does being overweight contribute to longer survival rates in myelodysplastic syndrome? Haematologica 2018 103:559-560.
Equipe DRC Mayeux-Bouscary

Haidar, M., Z. Rchiad, H. R. Ansari, F. Ben-Rached, S. Tajeri, P. Latre De Late, G. Langsley, and A. Pain. 
miR-126-5p by direct targeting of JNK-interacting protein-2 (JIP-2) plays a key role in Theileria-infected macrophage virulence. PLoS Pathog 2018 14:e1006942.
Equipe 3I Langsley

Diedisheim, M., M. Oshima, O. Albagli, C. W. Huldt, I. Ahlstedt, M. Clausen, S. Menon, A. Aivazidis, A. C. Andreasson, W. G. Haynes, P. Marchetti, L. Marselli, M. Armanet, F. Chimienti, and R. Scharfmann. 
Modeling human pancreatic beta cell dedifferentiation. Mol Metab 2018 10:74-86.
Equipe EMD Scharfmann

Le-Bury, G., and F. Niedergang. 
Defective Phagocytic Properties of HIV-Infected Macrophages: How Might They Be Implicated in the Development of Invasive Salmonella Typhimurium? Front Immunol 2018 9:531.
Equipe 3I Niedergang

Lores, P., C. Coutton, E. El Khouri, L. Stouvenel, M. Givelet, L. Thomas, B. Rode, A. Schmitt, B. Louis, Z. Sakheli, M. Chaudhry, A. Fernandez-Gonzales, A. Mitsialis, D. Dacheux, J. P. Wolf, J. F. Papon, G. Gacon, E. Escudier, C. Arnoult, M. Bonhivers, S. N. Savinov, S. Amselem, P. F. Ray, E. Dulioust, and A. Toure. 
Homozygous missense mutation L673P in adenylate kinase 7 (AK7) leads to primary male infertility and multiple morphological anomalies of the flagella but not to primary ciliary dyskinesia. Hum Mol Genet 2018 27:1196-1211. 
Equipe DRC Vaiman et plateforme de microscopie électronique A. Schmitt

Gruber, A., M. Pacault, L. A. El Khattabi, N. Vaucouleur, L. Orhant, T. Bienvenu, E. Girodon, D. Vidaud, F. Leturcq, C. Costa, F. Letourneur, O. Anselem, V. Tsatsaris, F. Goffinet, G. Viot, M. Vidaud, and J. Nectoux. 
Non-invasive prenatal diagnosis of paternally inherited disorders from maternal plasma: detection of NF1 and CFTR mutations using droplet digital PCR.  Clin Chem Lab Med 2018 56:728-738.
Equipe DRC Billuart-Bienvenu et plateforme GENOMI'C Letourneur

Bourdon, M., P. Santulli, C. Maignien, V. Gayet, K. Pocate-Cheriet, L. Marcellin, and C. Chapron.
The deferred embryo transfer strategy improves cumulative pregnancy rates in endometriosis-related infertility: A retrospective matched cohort study. PLoS One 2018 13:e0194800.
Equipe DRC Vaiman

Avouac, J., A. Molto, V. Abitbol, A. Etcheto, A. Salcion, L. Gutermann, C. Klotz, M. Elhai, P. Cohen, P. A. Soret, F. Morin, O. Conort, F. Chast, C. Goulvestre, C. L. Jeunne, S. Chaussade, A. Kahan, C. Roux, Y. Allanore, and M. Dougados. 
Systematic switch from innovator infliximab to biosimilar infliximab in inflammatory chronic diseases in daily clinical practice: The experience of Cochin University Hospital, Paris, France. Semin Arthritis Rheum 2018 47:741-748.
Equipe 3I Allanore

Kjobsted, R., J. R. Hingst, J. Fentz, M. Foretz, M. N. Sanz, C. Pehmoller, M. Shum, A. Marette, R. Mounier, J. T. Treebak, J. F. P. Wojtaszewski, B. Viollet, and L. Lantier. 
AMPK in skeletal muscle function and metabolism. FASEB J 2018 32:1741-1777.
Equipe EMD Vaulont-Viollet

Logerot, S., M. Rancez, B. Charmeteau-de Muylder, S. Figueiredo-Morgado, S. Rozlan, G. Tambussi, S. Beq, A. Couedel-Courteille, and R. Cheynier. 
HIV reservoir dynamics in HAART-treated poor immunological responder patients under IL-7 therapy. AIDS 2018 32:715-720.
Equipe 3I Cheynier

Del Giudice, P., C. Plainvert, T. Hubiche, A. Tazi, A. Fribourg, and C. Poyart.
Infectious Cellulitis Caused by Streptococcus halichoeri. Acta Derm Venereol 2018 98:378-379.
Equipe 3I Poyart-Fouet

Bracq, L., M. Xie, S. Benichou, and J. Bouchet. 
Mechanisms for Cell-to-Cell Transmission of HIV-1. Front Immunol 2018 9:260.
Equipe 3I Bénichou

Owino, S., A. Sanchez-Bretano, C. Tchio, E. Cecon, A. Karamitri, J. Dam, R. Jockers, G. Piccione, H. L. Noh, T. Kim, J. K. Kim, K. Baba, and G. Tosini. 
Nocturnal activation of melatonin receptor type 1 signaling modulates diurnal insulin sensitivity via regulation of PI3K activity. J Pineal Res 2018 64:e12462.
Equipe EMD Jockers

Hospital, M. A., A. Jacquel, F. Mazed, E. Saland, C. Larrue, J. Mondesir, R. Birsen, A. S. Green, M. Lambert, P. Sujobert, E. F. Gautier, V. Salnot, M. Le Gall, J. Decroocq, L. Poulain, N. Jacque, M. Fontenay, O. Kosmider, C. Recher, P. Auberger, P. Mayeux, D. Bouscary, J. E. Sarry, and J. Tamburini. 
RSK2 is a new Pim2 target with pro-survival functions in FLT3-ITD-positive acute myeloid leukemia. Leukemia 2018 32:597-605.
Equipe DRC Mayeux-Bouscary 

Romain, A. S., R. Cohen, C. Plainvert, C. Joubrel, S. Bechet, A. Perret, A. Tazi, C. Poyart, and C. Levy.
Clinical and Laboratory Features of Group B Streptococcus Meningitis in Infants and Newborns: Study of 848 Cases in France, 2001-2014. Clin Infect Dis 2018 66:857-864.
Equipe 3I Poyart-Fouet 

Menard, D., J. Clain, and F. Ariey. 
Multidrug-resistant Plasmodium falciparum malaria in the Greater Mekong subregion. Lancet Infect Dis 2018 18:238-239.
Equipe 3I Langsley

Niedergang, F., and S. Grinstein.
How to build a phagosome: new concepts for an old process.Curr Opin Cell Biol 2018 50:57-63.
Equipe 3I Niedergang

Richards, P., L. Rachdi, M. Oshima, P. Marchetti, M. Bugliani, M. Armanet, C. Postic, S. Guilmeau, and R. Scharfmann.
MondoA Is an Essential Glucose-Responsive Transcription Factor in Human Pancreatic beta-Cells. Diabetes 2018 67:461-472.
Equipes EMD Scharfmann et EMD Postic

Maillet, V., N. Boussetta, J. Leclerc, V. Fauveau, M. Foretz, B. Viollet, J. P. Couty, S. Celton-Morizur, C. Perret, and C. Desdouets. 
LKB1 as a Gatekeeper of Hepatocyte Proliferation and Genomic Integrity during Liver Regeneration.  Cell Rep 2018 22:1994-2005.
Equipes DRC DesdouetsDRC PerretEMD Vaulont-Viollet

Bonnet-Serrano, F., and J. Bertherat.
Genetics of tumors of the adrenal cortex. Endocr Relat Cancer 2018 25:R131-R152.
Equipe EMD Bertherat

Saidu, N. E. B., M. Bretagne, A. L. Mansuet, P. A. Just, K. Leroy, O. Cerles, S. Chouzenoux, C. Nicco, D. Damotte, M. Alifano, B. Borghese, F. Goldwasser, F. Batteux, and J. Alexandre. 
Dimethyl fumarate is highly cytotoxic in KRAS mutated cancer cells but spares non-tumorigenic cells. Oncotarget 2018 9:9088-99.
Equipe DRC Batteux

Coutton, C., A. S. Vargas, A. Amiri-Yekta, Z. E. Kherraf, S. F. Ben Mustapha, P. Le Tanno, C. Wambergue-Legrand, T. Karaouzene, G. Martinez, S. Crouzy, A. Daneshipour, S. H. Hosseini, V. Mitchell, L. Halouani, O. Marrakchi, M. Makni, H. Latrous, M. Kharouf, J. F. Deleuze, A. Boland, S. Hennebicq, V. Satre, P. S. Jouk, N. Thierry-Mieg, B. Conne, D. Dacheux, N. Landrein, A. Schmitt, L. Stouvenel, P. Lores, E. El Khouri, S. P. Bottari, J. Faure, J. P. Wolf, K. Pernet-Gallay, J. Escoffier, H. Gourabi, D. R. Robinson, S. Nef, E. Dulioust, R. Zouari, M. Bonhivers, A. Toure, C. Arnoult, and P. F. Ray. 
Mutations in CFAP43 and CFAP44 cause male infertility and flagellum defects in Trypanosoma and human. Nat Commun 2018 9:686.
Equipe DRC Vaiman

Randrianarison-Huetz, V., A. Papaefthymiou, G. Herledan, C. Noviello, U. Faradova, L. Collard, A. Pincini, E. Schol, J. F. Decaux, P. Maire, S. Vassilopoulos, and A. Sotiropoulos.
Srf controls satellite cell fusion through the maintenance of actin architecture. J Cell Biol 2018 217:685-700.
Equipe DRC Maire-Sotiropoulos

Garinet, S., J. Nectoux, M. Neou, E. Pasmant, A. Jouinot, M. Sibony, L. Orhant, J. Pipoli da Fonseca, K. Perlemoine, L. Bricaire, L. Groussin, O. Soubrane, B. Dousset, R. Libe, F. Letourneur, J. Bertherat, and G. Assie. 
Detection and monitoring of circulating tumor DNA in adrenocortical carcinoma. Endocr Relat Cancer 2018 25:L13-L17.
Equipes EMD Bertherat et DRC Billuart-Bienvenu et plateforme Genomi'C Letourneur

Kerdivel, G., V. Chesnais, E. Becht, A. Toma, N. Cagnard, F. Dumont, A. Rousseau, P. Fenaux, S. Chevret, N. Chapuis, V. Boeva, W. H. Fridman, M. Fontenay, and O. Kosmider.
Lenalidomide-mediated erythroid improvement in non-del(5q) myelodysplastic syndromes is associated with bone marrow immuno-remodeling. Leukemia 2018 32:558-562.
Equipes DRC Mayeux-Bouscary et DRC Boeva

Allanore, Y., O. Distler, M. Matucci-Cerinic, and C. P. Denton. 
Review: Defining a Unified Vascular Phenotype in Systemic Sclerosis. Arthritis Rheumatol 2018 70:162-170.
Equipe 3I Allanore

Bod, L., L. Douguet, C. Auffray, R. Lengagne, F. Bekkat, E. Rondeau, V. Molinier-Frenkel, F. Castellano, Y. Richard, and A. Prevost-Blondel. 
IL-4-Induced Gene 1: A Negative Immune Checkpoint Controlling B Cell Differentiation and Activation. J Immunol 2018 200:1027-1038.
Equipes 3I Hosmalin et 3I Lucas

Lebrun, N., I. Giurgea, A. Goldenberg, A. Dieux, A. Afenjar, J. Ghoumid, B. Diebold, L. Mietton, A. Briand-Suleau, P. Billuart, and T. Bienvenu.
Molecular and cellular issues of KMT2A variants involved in Wiedemann-Steiner syndrome. Eur J Hum Genet 2018 26:107-116.
Equipe DRC Billuart-Bienvenu

Bonnet-Serrano, F., M. Diedisheim, R. Mallone, and E. Larger. 
Decreased alpha-cell mass and early structural alterations of the exocrine pancreas in patients with type 1 diabetes: An analysis based on the nPOD repository. PLoS One 2018 13:e0191528.
Equipes EMD Scharfmann et EMD Lehuen Mallone

Moreno-Sabater, A., J. L. Perignon, D. Mazier, C. Lavazec, and V. Soulard. 
Humanized mouse models infected with human Plasmodium species for antimalarial drug discovery. Expert Opin Drug Discov 2018 13:131-140.
Equipe 3I Lavazec

Durand, A., A. Audemard-Verger, V. Guichard, R. Mattiuz, A. Delpoux, P. Hamon, N. Bonilla, M. Riviere, J. Delon, B. Martin, C. Auffray, A. Boissonnas, and B. Lucas.
Profiling the lymphoid-resident T cell pool reveals modulation by age and microbiota. Nat Commun 2018 9:68.
Equipes 3I Lucas et 3I Donnadieu-Randriamampita

Aymeric, L., F. Donnadieu, C. Mulet, L. du Merle, G. Nigro, A. Saffarian, M. Berard, C. Poyart, S. Robine, B. Regnault, P. Trieu-Cuot, P. J. Sansonetti, and S. Dramsi. 
Colorectal cancer specific conditions promote Streptococcus gallolyticus gut colonization. Proc Natl Acad Sci U S A 2018 115:E283-E291.
Equipe 3I Poyart-Fouet

Broche, B., S. Ben Fradj, E. Aguilar, T. Sancerni, M. Benard, F. Makaci, C. Berthault, R. Scharfmann, M. C. Alves-Guerra, and B. Duvillie. 
Mitochondrial Protein UCP2 Controls Pancreas Development. Diabetes 2018 67:78-84.
Equipe EMD Scharfmann

Zhou, Z., L. Xu, A. Sennepin, C. Federici, Y. Ganor, D. Tudor, D. Damotte, N. Barry Delongchamps, M. Zerbib, and M. Bomsel. 
The HIV-1 viral synapse signals human foreskin keratinocytes to secrete thymic stromal lymphopoietin facilitating HIV-1 foreskin entry. Mucosal Immunol 2018 11:158-171. 
Equipe 3I Bomsel

Fructuoso, M., L. Rachdi, E. Philippe, R. G. Denis, C. Magnan, H. Le Stunff, N. Janel, and M. Dierssen.
Increased levels of inflammatory plasma markers and obesity risk in a mouse model of Down syndrome. Free Radic Biol Med 114:122-130.
Equipe EMD Scharfmann

Broix, L., L. Asselin, C. G. Silva, E. L. Ivanova, P. Tilly, J. G. Gilet, N. Lebrun, H. Jagline, G. Muraca, Y. Saillour, N. Drouot, M. L. Reilly, F. Francis, A. Benmerah, N. Bahi-Buisson, R. Belvindrah, L. Nguyen, J. D. Godin, J. Chelly, and M. V. Hinckelmann. 
Ciliogenesis and cell cycle alterations contribute to KIF2A-related malformations of cortical development. Hum Mol Genet 2018 27:224-238.
Equipe DRC Billuart-Bienvenu