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L’hépatite E est responsable d’une inflammation aiguë ou chronique du foie. Il s’agit d’une maladie émergente parfois mortelle et sans traitement connu. La Ribavirine, utilisée en monothérapie pendant 3 mois permet de guérir la majorité des patients.


Exome sequencing revealed somatic mutations in PRKACA, which encodes the catalytic subunit of cyclic AMP–dependent protein kinase (protein kinase A [PKA]), in 8 of 10 adenomas (c.617A→C in 7 and c.595_596insCAC in 1).


Leptin normally enters the brain mediobasal hypothalamus (MBH) to decrease food intake and increase energy expenditure. Obesity is associated with resistance to high circulating leptin levels. 


Mangafodipir prevented motor and sensory dysfunction and demyelinating lesion formation. In mice, serum AOPPs decreased after 4 weeks of mangafodipir treatment.

JCI Batteux


The H19 gene controls the expression of several genes within the Imprinted Gene Network (IGN), involved in growth control of the embryo. However, the underlying mechanisms of this control remain elusive. Here, we identified the methyl-CpG-binding domain protein 1 MBD1 as a physical and functional partner of the H19 long noncoding RNA (lncRNA).